Fig. 7

RAGE-ERK-NF-κB was involved in the HG and cilostazol effects on A7r5 cells. a Representative immunoblots of RAGE, p-ERK, nuclear p65, IκBα, FAK, MMP-2, ICAM-1 and VCAM-1 expressions under treatment with HG, cilostazol and an ERK inhibitor (U0126). b Representative immunoblots of nuclear p65, RAGE, FAK, MMP-2, ICAM-1 and VCAM-1 expressions under treatment with HG, cilostazol and a nuclear p65 inhibitor (PDTA). Treatment with HG 30 mM and cilostazol 200 μM combined with U0126 and PDTA in A7r5 cells. Western blots were independently repeated three times, and the representative data are shown. GAPDH served as a loading control