Table 2 Roles of non-coding RNAs in hemodynamics-modulated endothelial function and dysfunction
From: Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium
| Â | Non-coding RNA | Classification | Direct target | Affected molecule | EC dysfunction/function | Ref |
|---|---|---|---|---|---|---|
Pro-atherogenic OS | miR | Â | ||||
miR-126-5p↓ | Antiproliferative miR | Dlk1↑ |  | Proliferation | 81 | |
miR-10a↓ | Anti-inflamatory miR | GATA6↑ | VCAM-1↑ | Inflammation | 60, 76 | |
|  |  | TAK1, βTRC↑ | NF-κB p65 ↑ | Inflammation | 74 | |
|  |  |  | E-sel, VCAM-1, ↑ | Inflammation | 74 | |
|  |  |  | IL-6, IL-8, MCP-1↑ | Inflammation | 74 | |
miR-92a↑ | Inflammatory miR | KLF2↓ | IL-6, MCP-1 ↑,TM↓ | Inflammation | 82 | |
miR-663↑ | Inflammatory miR | ? | KLF4↓ | Inflammation | 73 | |
miR-712↑ | Inflammatory miR | ↓TIMP | Souluble TNF-α↑ | Inflammation | 75 | |
miR-21↑ | Inflammatory miR | ↓PPARα | AP-1/VCAM-1, MCP-1↑ | Inflammation | 83 | |
miR-34a↑ | Inflammatory miR | ? | NF-κB/VCAM-1, ICAM-1↑ | Inflammation | 84 | |
miR-21↑ | Oxidative miR | SOD↓ | ? | Oxidation | 30 | |
miR17*↑ | Oxidative miR? | SOD, GPx, Trx2↓ | ? | Oxidation? | 30 | |
miR-92a↑ | NO-related miR | KLF2↓ | eNOS↓ | NO repression | 82 | |
Atheroprotective PS | miR | Â | ||||
miR-19a↑ | Anti-proliferative miR | CyclinA↓ | ? | Antiproliferation | 71 | |
miR-23b↑ | Anti-proliferative miR | E2F↓ | Rb phosphorylation↓ | Antiproliferation | 72 | |
| Â | Â | ? | CAK complex (repression) | Antiproliferation | 78 | |
miR-101↑ | Anti-proliferative miR | mTOR↓ | ? | Antiproliferation | 79 | |
miR-155↑ | Anti-proliferative miR | MYLK↓ | RhoA | Antiproliferation Anti-proliferation | 80 | |
miR-10a↑ | Anti-inflamatory miR | GATA6↓ | VCAM-1↓ | Anti-inflammation | 60, 76 | |
miR-146a↑ | Anti-inflammatory miR | IRAK↓ | NF-κB signaling↓ | Anti-inflammation | 85 | |
miR-708↑ | Anti-inflammatory miR | IKK-γ↓ | NF-κB signaling↓ | Anti-inflammation | 85 | |
miR-451↑ | Anti-inflammatory miR | IL-6R↓ | NF-κB signaling↓ | Anti-inflammation | 85 | |
miR-98↑ | Anti-inflammatory miR | CHUK↓ | NF-κB signaling↓ | Anti-inflammation | 85 | |
miR-92a↓ | Anti-inflammatory miR | KLF2↑ | TM ↑ | Anti-inflammation | 82 | |
|  | NO-related miR | KLF2↑ | eNOS↑ | NO production | 82 | |
miR-21↑ | NO-related miR | PTEN↓ | eNOS (phosphorylation)↑ | NO production | 87 | |
lncRNAs | Â | |||||
STEEL↓ | Turnover-related lnRNA |  | eNOS, KLF-2↑ | Turnover, migration | 93 | |
| Â | Â | Â | Â | NO production??? | Â | |
MANTIS↑ | Aligment-related lnRNA |  | Smad6, Sox18 | Cell alignment | 94 | |
| Â | Â | Â | Â | Angiogenesis | Â | |
LASSIE↑ | Aligment-related lnRNA |  |  | Cell alignment | 95 | |
| Â | Â | Â | Â | Cell-cell interaction | Â | |
LISPR1↑ | Migration-related lnRNA |  | S1PR1 signaling↑ | Migration | 96 | |