Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Regulatory mechanisms of B cell responses and the implication in B cell-related diseases

Fig. 2

Proposed model of the role of KDM4A and KDM4C in B cell activation. During activation by Tfh cell-mimicking signals, the induced demethylases, KDM4A and KDM4C, cooperate with NF-κB to upregulate the expression of Wdr5 by removing H3K9me3/me2. WDR5, a core subunit of the COMPASS histone H3K4 methyltransferase complex, in turn facilitates the transcription of Cdkn2a and Cdkn3 by elevating H3K4me3/me2. Both CDKN2A and CDKN3 are involved in the regulation of stimulated B cell proliferation

Back to article page