Table 3 Evaluation of synergistic interaction between some natural beta lactamase inhibitors in association with selected permeabilizers with no antibacterial activity on susceptibility of beta lactamase producer isolates to different beta lactam antibiotics
From: Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria
Mean inhibition zone (mm) / Susceptibility break points | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Permeabilizers | Ab- alone | ECG | ECG + GA | ECG + T | Quercetin | Q + GA | Q + T | Permeabilizers | Ab-alone | Gallic acid | Thymol |
aAntibiotics (Ab) | bAntibiotics (Ab) | ||||||||||
Escherichia coli 2 | |||||||||||
PRL ≥21 | 6/R | 6/R | 20/M | 23/S | 15/R | 19/M | 24/S | TZP ≥21 | 14/R | 20/M | 26/S |
CFP ≥21 | 6/R | 6/R | 16/M | 21/S | 16/M | 21/S | 25/S | SCF ≥22 | 14/R | 19/M | 20/M |
Acinetobacter baumannii 4 | |||||||||||
PRL | 6/R | 6/R | 19/M | 21/S | 16/R | 24/S | 21/S | TZP | 15/R | 20/M | 21/S |
CFP | 6/R | 6/R | 23/S | 20/M | 16/M | 20/M | 22/S | SCF | 14/R | 22/S | 23/S |
Pseudomonas aeruginosa 8 | |||||||||||
PRL | 12/R | 12/R | 16/R | 25/S | 18/S | 22/S | 20/S | TZP | 17/R | 23/S | 26/S |
CFP | 10/R | 10/R | 15/R | 21/S | 17/M | 20/M | 22/S | SCF | 15/R | 25/S | 21/M |
Pseudomonas aeruginosa 9 | |||||||||||
PRL | 6/R | 6/R | 18/S | 19/S | 12/R | 19/S | 21/S | TZP | 11/R | 22/S | 22/S |
CFP | 6/R | 6/R | 22/S | 25/S | 15/R | 22/S | 24/S | SCF | 12/R | 22/S | 25/S |
Enterobacter cloacae 13 | |||||||||||
PRL | 6/R | 6/R | 20/M | 23/S | 15/R | 20/M | 24/S | TZP | 20/M | 30/S | 27/S |
CFP | 6/R | 6/R | 18/M | 21/S | 18/M | 20/M | 23/S | SCF | 18/M | 25/S | 23/S |