| APA (mV) | APD75 (msec) | APD50 (msec) | APD20 (msec) | Beating rate interval (msec) | EDD (mV/msec) | LDD (mV/msec) | MDP (mV) | TP (mV) |
---|---|---|---|---|---|---|---|---|---|
Control, (n = 12) | 80 ± 6 | 140 ± 13 | 99 ± 13 | 54 ± 8 | 453 ± 28 | 0.13 ± 0.05 | 0.21 ± 0.04 | −55 ± 4 | −39 ± 3 |
AVP (0.1 μM), (n = 11) | 82 ± 8 | 164 ± 18 | 109 ± 16 | 65 ± 11 | 432 ± 35# | 0.08 ± 0.01 | 0.33 ± 0.05# | −60 ± 2 | −32 ± 5 |
AVP (1 μM), (n = 13) | 71 ± 7 | 121 ± 12 | 82 ± 8 | 43 ± 5 | 305 ± 21* | 0.09 ± 0.01 | 0.43 ± 0.06* | −53 ± 3 | −32 ± 2 |
AVP (1 μM) + OPC 21268 (0.1 μM), (n = 11) | 80 ± 6 | 131 ± 8 | 91 ± 7 | 48 ± 4 | 813 ± 213# | 0.08 ± 0.01 | 0.25 ± 0.03# | −56 ± 4 | −36 ± 3 |
AVP (1 μM) + OPC 41061 (10 nM), (n = 12) | 90 ± 4 | 142 ± 4 | 104 ± 3 | 58 ± 4 | 329 ± 22* | 0.11 ± 0.02 | 0.37 ± 0.02* | −54 ± 5 | −36 ± 3 |
OPC 21268 (0.1 μM), (n = 10) | 90 ± 4 | 148 ± 13 | 97 ± 10 | 57 ± 8 | 581 ± 100 | 0.09 ± 0.02 | 0.29 ± 0.03 | −62 ± 3 | −34 ± 3 |
OPC 41061 (10 nM), (n = 10) | 94 ± 4 | 158 ± 9 | 118 ± 8 | 70 ± 5 | 468 ± 52§ | 0.09 ± 0.01 | 0.24 ± 0.04§ | −59 ± 2 | −30 ± 3 |