Fig. 1
From: M2e-based universal influenza vaccines: a historical overview and new approaches to development
Analysis of M2e sequences of human, swine and avian influenza viruses. a Phylogenetic tree was generated from 27,253 human, 15,367 avian and 5379 swine individual sequences of influenza A virus M gene (obtained from the Influenza Research Database (fludb.org)) using MAFFT. The tree was visualized using the Interactive Tree Of Life (iTOL) server. b Prevalence of amino acid residues in M2e protein of selected M2e lineages. The consensus sequences for each lineage were obtained using UGENE Multiple Alignment software. Residues with a frequency below 3% are indicated with (*). c Proposed consensus M2e sequences for the development of a universal influenza vaccine