Enterovirus A71: virulence, antigenicity, and genetic evolution over the years

Table 1 EV-A71 genotype changes in endemic countries from 1997 to 2018

	Australia	Austria	China	Japan	Korea	Malaysia	Netherlands	Norway	Singapore	Taiwan	UK	Thailand	Vietnam
1997	B3		C2	B3,B4,C2		B3,B4,C1,C2	C1,C2		B3,B4,C1
1998	B3, C2		C4	C2		B4,C1			B3,C1	B3,B4,C2,C4	C1
1999	B3^ab, C2		C4	C2		B4,C1	C2		B3	B4,C2	C1,C2
2000	B4, C1		C4	B4,C2	C3	B4,C1	C2		B4,B5,C1	B4	C1
2001	B4,C1	C1	C4	C2	C3	B4,C1	C1		B4,C1	B4,C4	C1
2002	C1	C1	C2,C4	B4,C2,C4	C3	B4,C1	C1,C2	C1	B4,C1	B4,C4	C1
2003	C1,C4	C1,C4	C2,C4	B4,B5,C4	C3,C4	B4,B5,C1		C1	B4,B5,C1	B4,B5,C2
2004	C4	C4	C2,C4	C4		B5,C1	C1,C2		B5	C2,C4	C1
2005			C2,C4	C4	C3	B5,C1	C1,C2		B5	C2,C4,C5			C1,C4,C5
2006			C2,C4	C4		B5			B5	B5,C2,C4	C1,C2
2007			C2,C4	C2,C4	C4	B5	C1,C2		B5	B5,C5
2008			A,C2,C4	C2	C4	B5	C2		B5,C2	B5,C4,C5		B5,C1,C2,C4
2009	C2, C4		C2,C4	C2	C2,C4	B5,C1			B4,B5,C1	B5,C1		C1,C4
2010	B3, C2		C2,C4	C2	C4	B5				C4		B5	C5
2011			C4		C4	B5				B5,C4		B5	C4,C5
2012			C4	B5		B5				B5		B5,C4	B5,C4,C5
2013			C4	B5								B5	C4,C5
2014			C4										B5,C4,C5
2015
2016				C4									C4
2017				B5								B5
2018				B5

ISSN: 1423-0127