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Table 2 Brief overview of iPSC banks worldwide

From: Human iPSC banking: barriers and opportunities

Bank Name Location Profit Type Ownership Types of Diseases Number of iPSC Lines Investment (USD) Related Publication
California Institute for Regenerative Medicine (CIRM) USA Non-profit Government-owned 23 1556 $3000,000 [51,52,53]
Coriell Institute for Medical Research (Coriell)a USA Non-profit Government-owned 40 91 $4,250,000 from NIH
$10,000,000 from CIRM
[54,55,56]
Fujifilm Cellular Dynamics International (FCDI)b USA Profit Owned by Fujifilm N/A N/A $16,000,000 and shared grant of $6,300,000 from CIRM [57,58,59,60,61]
Center for iPS Cell Research and Application (CiRA) Japan Non-profit Government-owned 10 22 $27,383,000 [62,63,64,65,66,67]
European Bank for induced pluripotent Stem Cells (EBiSC) Europe Non-profit European Commission, private enterprises 36 815 EBiSC project- $38,423,189
EBiSC2 project- $9,931,047
[68,69,70,71]
Human Induced Pluripotent Stem Cell Initiative (HipSci) UK Non-profit Medical Research Council, Wellcome Trust 15 835 $20,500,000 [72,73,74,75,76,77]
Human Disease iPSC Consortium Resource Center (Taiwan Human Disease iPSC Consortium) Taiwan Non-profit Government-owned 20 78 N/A [78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94]
Institute of Physical and Chemical Research (RIKEN) Japan Non-profit Government-owned 68 480 $24,862,180 for all departments [95,96,97,98]
Korean National Stem Cell Bank (KSCB) Korea Non-profit Government-owned 0 15 N/A [99, 100]
WiCell Research Institute (WiCell) USA Non-profit University of Wisconsin-Madison 58 1316 N/A [101,102,103,104]
  1. aCoriell has its own iPSC depositories: (1) NIGMS Human Genetic Cell Repository (15 healthy donor-derived iPSC lines and 37 diseased iPSC lines); (2) NIA Aging Cell Repository (3 diseased iPSC lines); and (3) Allen Institute for Cell Science. By using CRISPR technology, the Allen Institute generates 36 fluorescent-tagged (EGFP/RFP) iPSC lines from one healthy donor, which produces a potent research tool by tagging different cellular organelles, proteins and compartments. Owing to Coriell’s expertise in cryopreservation and banking, Coriell was awarded with $10 million grant by CIRM to redeposit donor samples and iPSC lines from the Human iPSC Initiative project
  2. bFounded by James Thomson and now acquired by Fujifilm, FCDI is renowned for its episomal reprogramming technique. Unlike other banks, FCDI generates diverse iPSC-derived differentiated/progenitor cells that are available for purchase: iCells and donor-specific MyCells. Although FCDI does not function as an iPSC bank that offers iPSC lines, it partners with CIRM in carrying out two iPSC projects: (1) CIRM gave FCDI a grant of $16 million to generate 3 iPSC lines per person from 3000 healthy and diseased donors from the Human iPSC Initiative project; (2) the FCDI and Medical College of Wisconsin (MCW) together received $6.3 million from CIRM. FCDI aims to generating 250 iPSC lines and their cardiomyocytes derived from Caucasian and African-American donors to study left ventricular hypertrophy