Table 4 The frequency of alleles and genotypes of placental P21-rs1059234, P21-rs1801270 and TP53-rs1042522 polymorphisms in PE women and controls
|  | PE (n = 109) | Control (n = 112) | P-value | OR(95% CI) | BC P-value |
|---|---|---|---|---|---|
 P21-rs1059234 | |||||
 CC, n(%) | 89 (81.7) | 97 (86.6) | – | 1 | |
 CT, n(%) | 17 (15.6) | 13 (11.6) | 0.37 | 1.4 (0.6–3.1) | 0.38 |
 TT, n(%) | 3 (2.8) | 2 (1.8) | 0.60 | 1.6 (0.3–10) | 0.59 |
 Dominant (CT + TT vs. CC) | 0.32 | 1.4 (0.7–3) | 0.31 | ||
 Recessive (TT vs. CC + CT) | 0.63 | 1.6 (0.2–9.5) | 0.62 | ||
 C, n(%) | 195 (89.5) | 207 (92.4) | – | 1 | |
 T, n(%) | 23 (10.5) | 17 (7.6) | 0.3 | 1.4 (0.7–2.8) | – |
 P21-rs1801270 | |||||
 CC, n(%) | 95 (87.2) | 85 (75.9) | – | 1 | |
 CA, n(%) | 11 (10.1) | 26 (23.2) | 0.013 | 0.4 (0.2–0.8) | 0.010 |
 AA, n(%) | 3 (2.8) | 1 (0.9) | 0.40 | 2.7 (0.3–26.3) | 0.38 |
 Dominant (CA + AA vs. CC) | 0.034 | 0.5 (0.2–0.9) | 0.031 | ||
 Recessive (AA vs. CC + CA) | 0.33 | 3.1 (0.3–30.7) | 0.30 | ||
 C, n(%) | 201 (92) | 196 (87.5) | – | 1 | |
 A, n(%) | 17 (8) | 28 (12.5) | 0.1 | 0.6 (0.3–1.1) | – |
 TP53-rs1042522 | |||||
 GG, n(%) | 31 (28.4) | 21 (18.8) | – | 1 | |
 GC, n(%) | 45 (41.3) | 45 (40.2) | 0.27 | 0.7 (0.4–1.4) | 0.27 |
 CC, n(%) | 33 (30.3) | 46 (41.1) | 0.051 | 0.5 (0.2–1) | 0.045 |
 Dominant (GC + CC vs. GG) | 0.091 | 0.6 (0.3–1.1) | 0.090 | ||
 Recessive (CC vs. GG + GC) | 0.095 | 0.6 (0.4–1.1) | 0.094 | ||
 G, n(%) | 107 (49.1) | 87 (38.8) | – | 1 | |
 C, n(%) | 111 (50.9) | 137 (61.2) | 0.03 | 0.7 (0.4–1) | |