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Table 4 The frequency of alleles and genotypes of placental P21-rs1059234, P21-rs1801270 and TP53-rs1042522 polymorphisms in PE women and controls

From: Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women

 PE
(n = 109)
Control
(n = 112)
P-valueOR(95% CI)BC
P-value
P21-rs1059234
 CC, n(%)89 (81.7)97 (86.6)1
 CT, n(%)17 (15.6)13 (11.6)0.371.4 (0.6–3.1)0.38
 TT, n(%)3 (2.8)2 (1.8)0.601.6 (0.3–10)0.59
 Dominant (CT + TT vs. CC)0.321.4 (0.7–3)0.31
 Recessive (TT vs. CC + CT)0.631.6 (0.2–9.5)0.62
 C, n(%)195 (89.5)207 (92.4)1
 T, n(%)23 (10.5)17 (7.6)0.31.4 (0.7–2.8)
P21-rs1801270
 CC, n(%)95 (87.2)85 (75.9)1
 CA, n(%)11 (10.1)26 (23.2)0.0130.4 (0.2–0.8)0.010
 AA, n(%)3 (2.8)1 (0.9)0.402.7 (0.3–26.3)0.38
 Dominant (CA + AA vs. CC)0.0340.5 (0.2–0.9)0.031
 Recessive (AA vs. CC + CA)0.333.1 (0.3–30.7)0.30
 C, n(%)201 (92)196 (87.5)1
 A, n(%)17 (8)28 (12.5)0.10.6 (0.3–1.1)
TP53-rs1042522
 GG, n(%)31 (28.4)21 (18.8)1
 GC, n(%)45 (41.3)45 (40.2)0.270.7 (0.4–1.4)0.27
 CC, n(%)33 (30.3)46 (41.1)0.0510.5 (0.2–1)0.045
 Dominant (GC + CC vs. GG)0.0910.6 (0.3–1.1)0.090
 Recessive (CC vs. GG + GC)0.0950.6 (0.4–1.1)0.094
 G, n(%)107 (49.1)87 (38.8)1
 C, n(%)111 (50.9)137 (61.2)0.030.7 (0.4–1)
  1. BC P-value, Bonferroni corrected P-value