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Table 4 Indications with consideration about biomarkers in advanced cancers

From: Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway

 

Pembrolizumab

Nivolumab

Atezolizumab

Breast cancer, triple negative, first-line

–

–

IC ≥ 1%

Cervical cancer, second-line

CPS ≥ 1

–

–

Colorectal cancer, second-line

MSI-high

MSI-high

–

Esophageal cancer, second-line

CPS ≥10

–

–

Gastric cancer, second-line

CPS ≥1

–

–

Head and neck cancer, first-line

CPS ≥1

–

–

Non-small cell lung cancer, first-line

CPS ≥1

–

–

Urothelial carcinoma, first-line

CPS ≥10

–

IC ≥ 5%

Solid tumor, second-line

MSI-high

–

–

  1. CPS Combined positive score, IC Infiltrating immune cells, MSI Microsatellite instability