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Table 2 EV-A71 viral proteins target PRRs and innate immune regulators

From: Interplays between Enterovirus A71 and the innate immune system

Targeted PRRs and innate immune regulators Viral factor-mediated mechanisms References
TLR3 2A downregulates TLR3 [41]
TRIF 3C cleaves TRIF at Q312- S313 [43, 70]
RIG-I 1. 3C targets RIG-I
2. 3C degrades RIG-I
MDA5 1. 2A degrades MDA5
2. Host caspase cleaves MDA5
3. 3D interacts with the MDA5 CARD region
MAVS 2A cleaves MAVS at Gly209, Gly251, and Gly265 [43, 80]
NLRP3 1. 2A cleaves NLRP3 at Q225-G226
2. 3C cleaves NLRP3 G493-L494
GSMD 3C cleaves GSDMD at Q193-G194 [81]
TRAF6/IRAK1 Host miR-146a downregulates TRAF6/IRAK1 [76]
TAB2/TAK1/TAB1/TAB3 3C cleaves TAB2 at Q113-S114, TAK1 at Q360-S361, TAB1 at Q414-G415 and Q451-S452, and TAB3 at Q173-G174 and Q343-G344 [72]
IKKβ/p65 2C targets IKKβ and p65 [73, 74]
IRF7 3C cleaves IRF7 at Q189-S190 [71]
IRF9 3C cleaves IRF9 [82]
IFNAR1 2A downregulates IFNAR1 [83]
ZAP 3C cleaves ZAP at Q369 -G370 [84]