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Table 1 Kinetic analysis of the binding of the monoclonal antibodies 6A4G7 and 17A1D10 to the Dectin-2.Fc fusion protein

From: Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients

Anti-Dectin-2 monoclonal antibodyKa (association rate) (M−1·s− 1)Kd (disassociation rate) (s− 1)KD (disassociation constant) (M)
6A4G78.5 (± 6.4) × 1062.9 (± 1.6) × 10− 23.9 (± 0.9) × 10− 9
17A1D104.4 (± 2.8) × 1042.3 (± 0.2) × 10− 37.1 (± 2.1) × 10− 8
  1. Adherence of anti-Dectin-2 monoclonal antibodies to Dectin-2.Fc was measured in duplicate