Skip to main content

Table 1 Kinetic analysis of the binding of the monoclonal antibodies 6A4G7 and 17A1D10 to the Dectin-2.Fc fusion protein

From: Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients

Anti-Dectin-2 monoclonal antibody Ka (association rate) (M−1·s− 1) Kd (disassociation rate) (s− 1) KD (disassociation constant) (M)
6A4G7 8.5 (± 6.4) × 106 2.9 (± 1.6) × 10− 2 3.9 (± 0.9) × 10− 9
17A1D10 4.4 (± 2.8) × 104 2.3 (± 0.2) × 10− 3 7.1 (± 2.1) × 10− 8
  1. Adherence of anti-Dectin-2 monoclonal antibodies to Dectin-2.Fc was measured in duplicate