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Table 1 Multiparametric logistic regression analysis to express the relationship of classification by the combined BPA/UPA proteomic test with demographic and clinical variables for the prediction of overall survival within the first year of clinical follow-up after proteomic analysis. The regression coefficient in the table expresses the amount of change in the logit function related to one unit change in the predictor

From: Bile and urine peptide marker profiles: access keys to molecular pathways and biological processes in cholangiocarcinoma

Independent variable

Regression coefficient

Standard error

Significance level P

Odds ratio (95% CI)

BPA/UPA match

0.5170

0.2240

0.02

1.68 (1.08–2.60)

Age (year)

0.0056

0.0351

0.87

1.01 (0.94–1.08)

Gender (female = 0, male = 1)

−0.1811

1.1347

0.87

0.83 (0.09–7.71)

Alkaline phosphatase (U/L)

−0.0117

0.0065

0.07

0.99 (0.98–1.00)

γ-Glutamyltransferase (U/L)

0.0017

0.0016

0.31

1.00 (1.00–1.00)

Bilirubin (μmol/L)

−0.0088

0.0089

0.33

0.99 (0.97–1.01)

Leucocyte count (N)

0.00026

0.00017

0.12

1.00 (1.00–1.00)

C-reactive protein (mg/L)

0.0134

0.0103

0.20

1.01 (0.99–1.03)

Alanine aminotransferase (U/L)

−0.0071

0.0159

0.66

0.99 (0.96–1.02)

Aspartate aminotransferase (U/L)

0.0202

0.0249

0.42

1.02 (0.97–1.07)

Carbohydrate antigen 19–9 (kU/L)

0.000046

0.000092

0.62

1.00 (1.00–1.00)