Therapeutic applications of nucleic acid aptamers in microbial infections

Table 1 A summary of aptamers selected against bacterial cells or toxins using SELEX technique, since 2015 till today

Target type	Aptamer Name	Target	Aptamer Type	Sequence of the Aptamer (5′ to 3′)	Kd (nM)	Ref
Bacteria	Lyd-3	S. pneumoniae	DNA	TGACGAGCCCAAGTTACCTGCCCCCGAACCATACCACACG ATGCCCCGTACCCCAGCCACCAGAATCTCCGCTGCCTACA	661.8 ± 111.3	[29]
	Apt3	S. choleraesuis	DNA	GGCAGGACAACAGCGTGTAGTATCAGCTTACGGTG	41 ± 2	[11]
	BB16-11f	B. breve^a	DNA	CTCCCAGGCCGTTGGGGCGTTGCCTGCGT	18.66 ± 1.41	[30]
	CCFM641–5	B. bifidum^b	DNA	TGCGTGAGCGGTAGCCCCGTACGACCCACTGTGGTTGGGC	10.69 ± 0.89	[18]
	SAL 26	S.typhimurium	DNA	TAGCTCACTCATTAGGCACATTTGTGGCACCAAATTTGAATTAATCAAGACAGTGTGGTGCATAGTTAAGCCAGCC	123 ± 23	[31]
Bacterial toxin	CT916	cholera toxin	DNA	GGCAAAAAGGATTGCCCAGGTCTGCTGTCTAGCCGGATTC	48.5 ± 0.5	[32]
	S3	SEA	DNA	CCCGCCTCTGAGCATTATTAATGTTATACCTTACGGCTGG	36.93 ± 7.29	[33]
	ML12	LF	DNA	CGAGGGAGACGCGAACCTTCTCGCCTTGGG	11.0 ± 2.7	[34]
	C10	enterotoxin C1	DNA	AGCAGCACAGAGGTCAGATGTATACTTCTAAAATTTGTTTGT ATCTACGATGTTCTTCGTCCTATGCGTGCTACCGTGAA	65.14 ± 11.64	[35]

ISSN: 1423-0127