Fig. 1
From: Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling
A summary of hypoxia-induced phenotypes through regulation of EMT transcription factors (EMT-TFs) and EMT markers (EMT-Ms). Three different phenotypes, including metastasis, cancer stemness, and immune suppression, are described. They are regulated by different signaling pathways depicted. Blue arrows indicate regulation of EMT marker expression (i.e. repression of epithelial genes and activation of mesenchymal genes)