Journal of Biomedical Science

Table 3 Amino acid substitutions in the HA protein of H7N9 CVVs propagated in aMDCK or sMDCK cells

From: Development of high-growth influenza H7N9 prepandemic candidate vaccine viruses in suspension MDCK cells

CVVs	V1aM3^a	V1aM7^a	V1sM3^a	V1sM7^a
NHRI-RG3	I120T/I^b	I120T	I120I/T^b, G209E/G^b	I120T, K163R, A292T/A^b
NHRI-RG4	A151T	A151T	I120I/T^b	I120T/I^b, I421I/V/M^b
NHRI-RG5	No change	No change	No change	No change
NHRI-RG6	No change	No change	No change	No change

Note: ^aPassage history: V Vero cells, aM adherent MDCK cells, sM suspension MDCK cells. The number indicates the passage number in the indicated cells
^bMixed amino acid residues were detected

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ISSN: 1423-0127

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