Fig. 2

METTL3 is required for angiogenesis of human endothelial cells. a qRT-PCR and (b) western blot analysis of the knockdown efficiency of siRNA specifically target on METTL3 in endothelial cells. c Representative images and statistical analysis of cell migration assay for control and METTL3 deficient endothelial cells at the indicated times. d Representative bright-field images and statistical analysis of tube formation assay of control and METTL3 deficient endothelial cells. Data are shown as mean ± SEM of three independent experiments. P values were calculated using Student’s t-test. *, P < 0.05; **, P < 0.01; ***, P < 0.001