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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats

Fig. 6

The effect of knockdown TGR5 on BRCA1/Sirt1 expression and BBB permeability after MCAO. a The band of Western blot analysis; b The relative density of TGR5, BRCA1, Sirt1.n = 6 per group. TGR5 or BRCA1 knockout increased infarct volume (c), worsen neurobehavioral deficits (d), exacerbated brain water content (e) and BBB permeability (f). n = 6 per group. *P < 0.05 vs sham, #P < 0.05 vs MCAO+ Scr siRNA. Bars represent mean ± SEM. Scr siRNA, scramble siRNA

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Journal of Biomedical Science

ISSN: 1423-0127