Fig. 8From: Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in ratsProposed pathway in the present study. This study found that TGR5 agonist, INT777, could protect BBB and improve neurological outcomes after MCAO, which through BRCA1/Sirt1 signaling pathway after MCAO. Our findings suggest that TGR5 may serve as a potential new candidate to relieve brain injury after MCAOBack to article page