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Table 5 The interaction between 4 genome-wide association study-identified single nucleotide polymorphisms and lifestyle and clinical factors on the risk of pancreatic cancer risk

From: Validation of genome-wide association study-identified single nucleotide polymorphisms in a case-control study of pancreatic cancer from Taiwan

  rs2816938 (1q32.1, NR5A2) rs10094872 (8q24.21, MYC) rs9581943 (13q12.2, PDX1) rs4885093 (13q22.1, intergenic region)
  TT AT+AA AA TA + TT GG GA + AA AA AG + GG
  OR (95% CI)a OR (95% CI)a OR (95% CI)a OR (95% CI)a OR (95% CI)a OR (95% CI)a OR (95% CI)a OR (95% CI)a
Cigarette smoking
 Never Referent Referent Referent Referent Referent Referent Referent Referent
 Ever 1.32 (0.87–1.99) 7.41 (2.10–26.09) 1.51 (0.91–2.51) 1.92 (1.04–3.54) 2.04 (1.11–3.74) 1.39 (0.83–2.34) 0.85 (0.35–2.08) 1.91 (1.22–2.98)
  P-interaction = 0.07 P-interaction = 0.65 P-interaction = 0.73 P-interaction = 0.35
Oral hygiene scoreb
 0 (Good) Referent Referent Referent Referent Referent Referent Referent Referent
 1 1.51 (0.88–2.60) 2.97 (0.61–14.45) 1.65 (0.84–3.26) 1.63 (0.75–3.56) 2.07 (0.99–4.34) 1.30 (0.65–2.63) 2.06 (0.60–7.12) 1.50 (0.85–2.63)
 2 2.35 (1.39–3.98) 13.26 (2.79–63.06) 2.83 (1.47–5.46) 2.93 (1.37–6.24) 2.72 (1.31–5.65) 2.71 (1.39–5.31) 3.75 (1.14–12.34) 2.55 (1.48–4.42)
 3 (Poor) 3.78 (2.01–7.10) 17.64 (2.37–131.31) 4.17 (1.91–9.09) 4.74 (1.87–11.98) 4.12 (1.67–10.21) 4.20 (1.89–9.37) 4.35 (1.11–17.09) 4.37 (2.23–8.57)
  P-interaction = 0.21 P-interaction = 0.73 P-interaction = 0.66 P-interaction = 0.68
 Every 1 point increment 1.57 (1.30–1.90) 2.83 (1.65–4.84) 1.64 (1.31–2.07) 1.75 (1.33–2.31) 1.58 (1.22–2.06) 1.72 (1.35–2.19) 1.63 (1.11–2.40) 1.68 (1.38–2.05)
  P-interaction = 0.047 P-interaction = 0.71 P-interaction = 0.62 P-interaction = 0.38
Allergy
 No Referent Referent Referent Referent Referent Referent Referent Referent
 Yes 0.44 (0.29–0.65) 0.51 (0.21–1.23) 0.36 (0.22–0.59) 0.61 (0.36–1.05) 0.42 (0.25–0.73) 0.49 (0.30–0.79) 0.26 (0.12–0.61) 0.54 (0.36–0.81)
  P-interaction = 0.83 P-interaction = 0.16 P-interaction = 0.77 P-interaction = 0.07
Diabetes mellitus/glucose intolerance (DM/GI)
 No DM/GI Referent Referent Referent Referent Referent Referent Referent Referent
  < 2 years 5.61 (2.43–12.98) 1.29 (0.30–5.52) 2.67 (1.08–6.61) 8.94 (2.34–34.23) 6.20 (2.03–18.93) 2.83 (1.12–7.11) 9.11 (2.04–40.72) 3.18 (1.42–7.12)
  > 2 years 3.37 (2.09–5.44) 18.50 (2.09–163.62) 3.84 (2.13–6.92) 3.48 (1.68–7.19) 4.05 (2.02–8.10) 3.27 (1.76–6.07) 4.54 (1.67–12.33) 3.70 (2.19–6.26)
  P-interaction = 0.06 P-interaction = 0.32 P-interaction = 0.46 P-interaction = 0.47
Vegetable consumption
 3 portions or less per week Referent Referent Referent Referent Referent Referent Referent Referent
  > 3 portions per week 0.28 (0.19–0.40) 0.41 (0.16–1.06) 0.27 (0.17–0.42) 0.34 (0.20–0.59) 0.28 (0.17–0.48) 0.31 (0.20–0.50) 0.22 (0.10–0.48) 0.31 (0.21–0.46)
  P-interaction = 0.43 P-interaction = 0.49 P-interaction = 0.71 P-interaction = 0.55
Fruit consumption
 1 portion or less per day Referent Referent Referent Referent Referent Referent Referent Referent
  > 1 portion per day 0.74 (0.51–1.07) 0.44 (0.16–1.21) 0.77 (0.50–1.20) 0.63 (0.36–1.08) 0.80 (0.47–1.37) 0.71 (0.45–1.11) 0.76 (0.38–1.51) 0.68 (0.46–1.01)
  P-interaction = 0.55 P-interaction = 0.56 P-interaction = 0.88 P-interaction = 0.76
BMI 2 years agoc
  < 27 Referent Referent Referent Referent Referent Referent Referent Referent
 27 or more 2.21 (1.53–3.20) 1.45 (0.54–3.90) 2.00 (1.29–3.09) 2.37 (1.34–4.19) 1.13 (0.63–2.00) 2.99 (1.89–4.72) 1.48 (0.64–3.42) 2.37 (1.61–3.49)
  P-interaction = 0.46 P-interaction = 0.67 P-interaction = 0.009 P-interaction = 0.18
  1. Abbreviations: BMI body mass index, CI confidence interval, DM/GI diabetes mellitus/glucose intolerance, OR odds ratio
  2. aOR and 95% CI were calculated using unconditional logistic regression, adjusted for sex, age, and education
  3. bOral hygiene score = tooth brushing + use of dental floss + regular dental visit, with tooth brushing: 2 times per day = 0, < 2 times per day = 1; use of dental floss: yes = 0, no = 1; and regular dental visit: yes = 0, no = 1
  4. cBMI at two years before the pancreatic cancer diagnosis for the cases or before the interview date for the controls