Table 5 The interaction between 4 genome-wide association study-identified single nucleotide polymorphisms and lifestyle and clinical factors on the risk of pancreatic cancer risk
rs2816938 (1q32.1, NR5A2) | rs10094872 (8q24.21, MYC) | rs9581943 (13q12.2, PDX1) | rs4885093 (13q22.1, intergenic region) | |||||
|---|---|---|---|---|---|---|---|---|
TT | AT+AA | AA | TA + TT | GG | GA + AA | AA | AG + GG | |
OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | |
Cigarette smoking | ||||||||
 Never | Referent | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
 Ever | 1.32 (0.87–1.99) | 7.41 (2.10–26.09) | 1.51 (0.91–2.51) | 1.92 (1.04–3.54) | 2.04 (1.11–3.74) | 1.39 (0.83–2.34) | 0.85 (0.35–2.08) | 1.91 (1.22–2.98) |
P-interaction = 0.07 | P-interaction = 0.65 | P-interaction = 0.73 | P-interaction = 0.35 | |||||
Oral hygiene scoreb | ||||||||
 0 (Good) | Referent | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
 1 | 1.51 (0.88–2.60) | 2.97 (0.61–14.45) | 1.65 (0.84–3.26) | 1.63 (0.75–3.56) | 2.07 (0.99–4.34) | 1.30 (0.65–2.63) | 2.06 (0.60–7.12) | 1.50 (0.85–2.63) |
 2 | 2.35 (1.39–3.98) | 13.26 (2.79–63.06) | 2.83 (1.47–5.46) | 2.93 (1.37–6.24) | 2.72 (1.31–5.65) | 2.71 (1.39–5.31) | 3.75 (1.14–12.34) | 2.55 (1.48–4.42) |
 3 (Poor) | 3.78 (2.01–7.10) | 17.64 (2.37–131.31) | 4.17 (1.91–9.09) | 4.74 (1.87–11.98) | 4.12 (1.67–10.21) | 4.20 (1.89–9.37) | 4.35 (1.11–17.09) | 4.37 (2.23–8.57) |
P-interaction = 0.21 | P-interaction = 0.73 | P-interaction = 0.66 | P-interaction = 0.68 | |||||
 Every 1 point increment | 1.57 (1.30–1.90) | 2.83 (1.65–4.84) | 1.64 (1.31–2.07) | 1.75 (1.33–2.31) | 1.58 (1.22–2.06) | 1.72 (1.35–2.19) | 1.63 (1.11–2.40) | 1.68 (1.38–2.05) |
P-interaction = 0.047 | P-interaction = 0.71 | P-interaction = 0.62 | P-interaction = 0.38 | |||||
Allergy | ||||||||
 No | Referent | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
 Yes | 0.44 (0.29–0.65) | 0.51 (0.21–1.23) | 0.36 (0.22–0.59) | 0.61 (0.36–1.05) | 0.42 (0.25–0.73) | 0.49 (0.30–0.79) | 0.26 (0.12–0.61) | 0.54 (0.36–0.81) |
P-interaction = 0.83 | P-interaction = 0.16 | P-interaction = 0.77 | P-interaction = 0.07 | |||||
Diabetes mellitus/glucose intolerance (DM/GI) | ||||||||
 No DM/GI | Referent | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
  < 2 years | 5.61 (2.43–12.98) | 1.29 (0.30–5.52) | 2.67 (1.08–6.61) | 8.94 (2.34–34.23) | 6.20 (2.03–18.93) | 2.83 (1.12–7.11) | 9.11 (2.04–40.72) | 3.18 (1.42–7.12) |
  > 2 years | 3.37 (2.09–5.44) | 18.50 (2.09–163.62) | 3.84 (2.13–6.92) | 3.48 (1.68–7.19) | 4.05 (2.02–8.10) | 3.27 (1.76–6.07) | 4.54 (1.67–12.33) | 3.70 (2.19–6.26) |
P-interaction = 0.06 | P-interaction = 0.32 | P-interaction = 0.46 | P-interaction = 0.47 | |||||
Vegetable consumption | ||||||||
 3 portions or less per week | Referent | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
  > 3 portions per week | 0.28 (0.19–0.40) | 0.41 (0.16–1.06) | 0.27 (0.17–0.42) | 0.34 (0.20–0.59) | 0.28 (0.17–0.48) | 0.31 (0.20–0.50) | 0.22 (0.10–0.48) | 0.31 (0.21–0.46) |
P-interaction = 0.43 | P-interaction = 0.49 | P-interaction = 0.71 | P-interaction = 0.55 | |||||
Fruit consumption | ||||||||
 1 portion or less per day | Referent | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
  > 1 portion per day | 0.74 (0.51–1.07) | 0.44 (0.16–1.21) | 0.77 (0.50–1.20) | 0.63 (0.36–1.08) | 0.80 (0.47–1.37) | 0.71 (0.45–1.11) | 0.76 (0.38–1.51) | 0.68 (0.46–1.01) |
P-interaction = 0.55 | P-interaction = 0.56 | P-interaction = 0.88 | P-interaction = 0.76 | |||||
BMI 2 years agoc | ||||||||
  < 27 | Referent | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
 27 or more | 2.21 (1.53–3.20) | 1.45 (0.54–3.90) | 2.00 (1.29–3.09) | 2.37 (1.34–4.19) | 1.13 (0.63–2.00) | 2.99 (1.89–4.72) | 1.48 (0.64–3.42) | 2.37 (1.61–3.49) |
P-interaction = 0.46 | P-interaction = 0.67 | P-interaction = 0.009 | P-interaction = 0.18 | |||||