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Table 3 Pneumococcal serotypes, clinical characters and laboratory findings of children with pneumococcal pneumonia according to vaccination status and type of vaccine received

From: The potential role of pneumococcal conjugate vaccine in reducing acute respiratory inflammation in community-acquired pneumococcal pneumonia

 

Received pneumococcal vaccine

p-valueb

Received pneumococcal vaccine

No

Yes

PCV7

PCV 13

N = 562

N = 421

N = 316

N = 120

Probable pneumococcal pneumonia

487 (86.6)

363 (86.2)

 

274 (86.7)

104 (86.7)

Definitive pneumococcal pneumonia

75 (13.4)

58 (13.8)

0.845

42 (13.3)

16 (13.3)

Serotype--

 Type 3

12 (2.1)

7 (1.7)

0.594

6 (1.9)

1 (0.8)

 Type 6

1 (0.2)

1 (0.2)

1.000

0

1 (0.8)

 Type 14

1 (0.2)

1 (0.2)

1.000

0

1 (0.8)

 Type 19A

29 (5.2)

27 (6.4)

0.402

22 (7.0)

6 (5.0)

 Type 19F

1 (0.2)

2 (0.5)

0.580

1 (0.3)

1 (0.8)

 Unknown

518 (91.1)

383 (90.9)

0.502

287 (90.8)

110 (91.7)

Processing of pneumonia severity

 Pleural fluid aspiration

61 (10.9)

38 (9.0)

0.346

27 (8.5)

10 (8.3)

 Chest catheter

86 (15.3)

58 (13.8)

0.503

45 (14.2)

13 (10.8)

 VATS

54 (9.6)

43 (10.2)

0.753

31 (9.8)

12 (10.0)

 ICU admission

132 (23.5)

946 (22.3)

0.669

71 (22.5)

22 (18.3)

 Days in ICU

9.6 ± 11.0

7.2 ± 8.1

0.058c

7.1 ± 8.4

7.1 ± 7.5

 O2 use

195 (34.7)

155 (36.8)

0.492

108 (34.2)

46 (38.3)

 O2 use day >=7 days

60 (10.7)

49 (11.6)

0.634

37 (11.7)

12 (10.0)

 Admission days >= 14 days

95 (16.9)

69 (16.4)

0.831

52 (16.5)

16 (13.3)

Blood tests

 Lowest Hb (g/ dl)

11.6 ± 3.7

11.4 ± 1.5

0.289c

11.5 ± 1.4

11.4 ± 1.6

 Highest WBC (x k/ cumm)

14.0 ± 9.1

13.9 ± 8.3

0.832c

13.8 ± 8.7

14.1 ± 7.6

 Lowest WBC (x k/ cumm)

8.8 ± 4.8

9.5 ± 5.7

0.026c

9.5 ± 6.0

9.9 ± 5.3 a

 Highest Bandemia (%)

7.2 ± 11.8

6.1 ± 10.2

0.128c

6.2 ± 10.7

5.4 ± 8.2 a

 Highest Neutrophils (x k/ cumm)

34.0 ± 32.3

27.9 ± 29.9

0.003c

33.3 ± 32.1

12.2 ± 14.0 a

 Highest Lymphocytes (x k/ cumm)

12.5 ± 15.5

10.2 ± 14.8

0.021c

12.6 ± 16.0

3.3 ± 7.3 a

 Highest Eosinophils (x k/ cumm)

0.9 ± 2.0

1.2 ± 3.4

0.083c

0.9 ± 1.7

2.2 ± 5.7 a

 Highest Platelets (x k/ cumm)

368.1 ± 200.9

366.2 ± 196.5

0.883c

360.0 ± 199.1

377.1 ± 194.6

 Highest CRP (mg/ dl)

13.2 ± 12.4

10.9 ± 11.0

0.002c

11.5 ± 11.4 a

8.9 ± 9.5 a

  1. -- defined by PCR results
  2. Data are shown as N (%) for categorical variable and mean ± standard deviation for continuous variable, VATS, video-assisted thoracoscopic surgery; ICU, intensive care unit
  3. Numbers in bold indicate statistical significance (p<0.05)
  4. a significantly different from non-vaccination group
  5. b Chi-square test
  6. c Student's t-test