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Table 3 Pneumococcal serotypes, clinical characters and laboratory findings of children with pneumococcal pneumonia according to vaccination status and type of vaccine received

From: The potential role of pneumococcal conjugate vaccine in reducing acute respiratory inflammation in community-acquired pneumococcal pneumonia

  Received pneumococcal vaccine p-valueb Received pneumococcal vaccine
No Yes PCV7 PCV 13
N = 562 N = 421 N = 316 N = 120
Probable pneumococcal pneumonia 487 (86.6) 363 (86.2)   274 (86.7) 104 (86.7)
Definitive pneumococcal pneumonia 75 (13.4) 58 (13.8) 0.845 42 (13.3) 16 (13.3)
Serotype--
 Type 3 12 (2.1) 7 (1.7) 0.594 6 (1.9) 1 (0.8)
 Type 6 1 (0.2) 1 (0.2) 1.000 0 1 (0.8)
 Type 14 1 (0.2) 1 (0.2) 1.000 0 1 (0.8)
 Type 19A 29 (5.2) 27 (6.4) 0.402 22 (7.0) 6 (5.0)
 Type 19F 1 (0.2) 2 (0.5) 0.580 1 (0.3) 1 (0.8)
 Unknown 518 (91.1) 383 (90.9) 0.502 287 (90.8) 110 (91.7)
Processing of pneumonia severity
 Pleural fluid aspiration 61 (10.9) 38 (9.0) 0.346 27 (8.5) 10 (8.3)
 Chest catheter 86 (15.3) 58 (13.8) 0.503 45 (14.2) 13 (10.8)
 VATS 54 (9.6) 43 (10.2) 0.753 31 (9.8) 12 (10.0)
 ICU admission 132 (23.5) 946 (22.3) 0.669 71 (22.5) 22 (18.3)
 Days in ICU 9.6 ± 11.0 7.2 ± 8.1 0.058c 7.1 ± 8.4 7.1 ± 7.5
 O2 use 195 (34.7) 155 (36.8) 0.492 108 (34.2) 46 (38.3)
 O2 use day >=7 days 60 (10.7) 49 (11.6) 0.634 37 (11.7) 12 (10.0)
 Admission days >= 14 days 95 (16.9) 69 (16.4) 0.831 52 (16.5) 16 (13.3)
Blood tests
 Lowest Hb (g/ dl) 11.6 ± 3.7 11.4 ± 1.5 0.289c 11.5 ± 1.4 11.4 ± 1.6
 Highest WBC (x k/ cumm) 14.0 ± 9.1 13.9 ± 8.3 0.832c 13.8 ± 8.7 14.1 ± 7.6
 Lowest WBC (x k/ cumm) 8.8 ± 4.8 9.5 ± 5.7 0.026c 9.5 ± 6.0 9.9 ± 5.3 a
 Highest Bandemia (%) 7.2 ± 11.8 6.1 ± 10.2 0.128c 6.2 ± 10.7 5.4 ± 8.2 a
 Highest Neutrophils (x k/ cumm) 34.0 ± 32.3 27.9 ± 29.9 0.003c 33.3 ± 32.1 12.2 ± 14.0 a
 Highest Lymphocytes (x k/ cumm) 12.5 ± 15.5 10.2 ± 14.8 0.021c 12.6 ± 16.0 3.3 ± 7.3 a
 Highest Eosinophils (x k/ cumm) 0.9 ± 2.0 1.2 ± 3.4 0.083c 0.9 ± 1.7 2.2 ± 5.7 a
 Highest Platelets (x k/ cumm) 368.1 ± 200.9 366.2 ± 196.5 0.883c 360.0 ± 199.1 377.1 ± 194.6
 Highest CRP (mg/ dl) 13.2 ± 12.4 10.9 ± 11.0 0.002c 11.5 ± 11.4 a 8.9 ± 9.5 a
  1. -- defined by PCR results
  2. Data are shown as N (%) for categorical variable and mean ± standard deviation for continuous variable, VATS, video-assisted thoracoscopic surgery; ICU, intensive care unit
  3. Numbers in bold indicate statistical significance (p<0.05)
  4. a significantly different from non-vaccination group
  5. b Chi-square test
  6. c Student's t-test