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Table 2 Survival of BALB/c mice after vaccination and challenge with LD50 of S. Typhimurium SL1344a

From: Constructing conjugate vaccine against Salmonella Typhimurium using lipid-A free lipopolysaccharide

entry PS–protein vaccineb mortality at day 28c survival rate (%) hazard ratio
(95% CI)d
p-valuee vaccine efficacy (%)f
1 PBS 5/9 44.4
2 7a (BSA) 3/10 70.0 0.435 0.278 56.5
3 7b (OVA) 2/9 77.8 0.395 0.239 60.5
4 7c (FliC) 2/10 80.0 0.259 0.098 74.1
5 8b (FliC) 2/9 77.8 0.395 0.239 60.5
6 9b (FliC) 3/10 70.0 0.378 0.216 62.2
  1. a Mice were orally challenged with 1 × 106 CFU (LD50) S. Typhimurium SL1344 bacteria
  2. b The PS − protein conjugates 7a9b were prepared from unfractionated LFPS of 23 kDa
  3. c Number of dead mice over total number of test mice
  4. d Cox proportional hazard model results for the risk of death after challenge of S. Typhimurium SL1344 bacteria. CI is confidence interval
  5. e Comparison of survival distribution with the PBS group (negative control). The statistics are performed by log-rank test
  6. f Vaccine efficacy = (1 – hazard ratio) × 100%