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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma

Fig. 2

MGMT modulated CDDP-induced RAD51 expression in NPC cells. a HONE-1 and b TW01 cells transfected with scrambled or two independent MGMT-targeted siRNAs were treated with CDDP for 8 h. Fold changes in protein levels listed under each blot were normalized to the levels of the actin control. Following treatment with CDDP as indicated in a, b, the mRNA levels of c HONE-1 and d TW01cells transfected with scrambled or MGMT-targeted siRNA were quantified using qPCR. Representative results of at least three independent experiments are presented. Bar values are presented as mean ± SD of at least three independent experiments. *P < 0.05. e The correlation between MGMT and RAD51 expression levels in patients with NPC (GSE102349) was analyzed using Pearson correlation analyses. The correlation coefficient and P are indicated

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Journal of Biomedical Science

ISSN: 1423-0127