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Table 2 List of enriched Kyoto encyclopedia of genes and genomes (KEGG) pathways in the differentially expressed genes (DEG)s of acetate-grown C. glabrata cells

From: Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata

KEGG entry Pathway Count Frequency (%) EASE score
Up-regulated DEGs
 cgr00190 Oxidative phosphorylation 25 3.36 5.76E−09
 cgr04011 MAPK signalling pathway—yeast 13 1.75 2.54E−04
 cgr00020 Citrate cycle (TCA cycle) 9 1.21 0.006
 cgr03420 Nucleotide excision repair 10 1.34 0.0073
 cgr04146 Peroxisome 10 1.34 0.0073
 cgr03440 Homologous recombination 7 0.94 0.011
 cgr04144 Endocytosis 14 1.88 0.0133
 cgr04141 Protein processing in endoplasmic reticulum 14 1.88 0.047
 cgr00630 Glyoxylate and dicarboxylate metabolism 6 0.81 0.0519
 cgr01200 Carbon metabolism 16 2.15 0.0596
Down-regulated DEGs
 cgr01230 Biosynthesis of amino acids 69 9.43 8.67E−29
 cgr01100 Metabolic pathways 180 24.59 2.96E−28
 cgr01110 Biosynthesis of secondary metabolites 100 13.66 5.22E−21
 cgr01130 Biosynthesis of antibiotics 70 9.56 6.25E−13
 cgr01210 2-Oxocarboxylic acid metabolism 23 3.14 2.32E−10
 cgr00260 Glycine, serine and threonine metabolism 18 2.46 1.28E−07
 cgr00300 Lysine biosynthesis 11 1.5 4.06E−07
 cgr00290 Valine, leucine and isoleucine biosynthesis 10 1.37 7.62E−06
 cgr00400 Phenylalanine, tyrosine and tryptophan biosynthesis 12 1.64 1.41E−05
 cgr00270 Cysteine and methionine metabolism 16 2.19 4.55E−05
 cgr00920 Sulfur metabolism 8 1.09 4.20E−04
 cgr00450 Selenocompound metabolism 7 0.96 0.0017
 cgr00100 Steroid biosynthesis 9 1.23 0.0023
 cgr00670 One carbon pool by folate 8 1.09 0.0071
 cgr00510 N-Glycan biosynthesis 11 1.5 0.0099
 cgr00514 Other types of O-glycan biosynthesis 6 0.82 0.012
 cgr00564 Glycerophospholipid metabolism 12 1.64 0.0184
 cgr00680 Methane metabolism 9 1.23 0.0195
 cgr00010 Glycolysis/gluconeogenesis 14 1.91 0.0251
 cgr00340 Histidine metabolism 6 0.82 0.0287
 cgr00770 Pantothenate and CoA biosynthesis 7 0.96 0.0289
 cgr00220 Arginine biosynthesis 7 0.96 0.0289
 cgr00460 Cyanoamino acid metabolism 4 0.55 0.0303
 cgr00230 Purine metabolism 21 2.87 0.0405
 cgr01200 Carbon metabolism 23 3.14 0.0468
 cgr00860 Porphyrin and chlorophyll metabolism 7 0.96 0.0508
 cgr00261 Monobactam biosynthesis 3 0.41 0.0665
 cgr00660 C5-Branched dibasic acid metabolism 3 0.41 0.0665
 cgr00051 Fructose and mannose metabolism 7 0.96 0.0808
 cgr00240 Pyrimidine metabolism 16 2.19 0.0929