Table 2 List of enriched Kyoto encyclopedia of genes and genomes (KEGG) pathways in the differentially expressed genes (DEG)s of acetate-grown C. glabrata cells

Up-regulated DEGs

 cgr00190

Oxidative phosphorylation

25

3.36

5.76E−09

 cgr04011

MAPK signalling pathway—yeast

13

1.75

2.54E−04

 cgr00020

Citrate cycle (TCA cycle)

9

1.21

0.006

 cgr03420

Nucleotide excision repair

10

1.34

0.0073

 cgr04146

Peroxisome

10

1.34

0.0073

 cgr03440

Homologous recombination

7

0.94

0.011

 cgr04144

Endocytosis

14

1.88

0.0133

 cgr04141

Protein processing in endoplasmic reticulum

14

1.88

0.047

 cgr00630

Glyoxylate and dicarboxylate metabolism

6

0.81

0.0519

 cgr01200

Carbon metabolism

16

2.15

0.0596

Down-regulated DEGs

 cgr01230

Biosynthesis of amino acids

69

9.43

8.67E−29

 cgr01100

Metabolic pathways

180

24.59

2.96E−28

 cgr01110

Biosynthesis of secondary metabolites

100

13.66

5.22E−21

 cgr01130

Biosynthesis of antibiotics

70

9.56

6.25E−13

 cgr01210

2-Oxocarboxylic acid metabolism

23

3.14

2.32E−10

 cgr00260

Glycine, serine and threonine metabolism

18

2.46

1.28E−07

 cgr00300

Lysine biosynthesis

11

1.5

4.06E−07

 cgr00290

Valine, leucine and isoleucine biosynthesis

10

1.37

7.62E−06

 cgr00400

Phenylalanine, tyrosine and tryptophan biosynthesis

12

1.64

1.41E−05

 cgr00270

Cysteine and methionine metabolism

16

2.19

4.55E−05

 cgr00920

Sulfur metabolism

8

1.09

4.20E−04

 cgr00450

Selenocompound metabolism

7

0.96

0.0017

 cgr00100

Steroid biosynthesis

9

1.23

0.0023

 cgr00670

One carbon pool by folate

8

1.09

0.0071

 cgr00510

N-Glycan biosynthesis

11

1.5

0.0099

 cgr00514

Other types of O-glycan biosynthesis

6

0.82

0.012

 cgr00564

Glycerophospholipid metabolism

12

1.64

0.0184

 cgr00680

Methane metabolism

9

1.23

0.0195

 cgr00010

Glycolysis/gluconeogenesis

14

1.91

0.0251

 cgr00340

Histidine metabolism

6

0.82

0.0287

 cgr00770

Pantothenate and CoA biosynthesis

7

0.96

0.0289

 cgr00220

Arginine biosynthesis

7

0.96

0.0289

 cgr00460

Cyanoamino acid metabolism

4

0.55

0.0303

 cgr00230

Purine metabolism

21

2.87

0.0405

 cgr01200

Carbon metabolism

23

3.14

0.0468

 cgr00860

Porphyrin and chlorophyll metabolism

7

0.96

0.0508

 cgr00261

Monobactam biosynthesis

3

0.41

0.0665

 cgr00660

C5-Branched dibasic acid metabolism

3

0.41

0.0665

 cgr00051

Fructose and mannose metabolism

7

0.96

0.0808

 cgr00240

Pyrimidine metabolism

16

2.19

0.0929