Fig. 2
From: FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis
Downregulation of FKBP10 reduced proliferation of glioma cells in vitro and in vivo. a, b Western blot analysis and immunocytochemistry assays of FKBP10 expression in 10 glioma cell lines. c The results of CCK-8 cell proliferation tests in FKBP10 parental, scramble, siRNAs groups of U118MG and LN229 cells. d Representative images of colony formation assays in FKBP10 parental, scramble, siRNAs groups of U118MG and LN229 cells. Statistical results of colony number. e Image of subcutaneous tumors in nude mice. Statistical results showed that tumor volume and weight were significantly decreased in FKBP10 shRNA group. f Images of T2-weighted MRI showed intracranial xenografts of FKBP10-shRNA group grew slower than that of control group. The data are represented as means ± SD. **P < 0.01, ***P < 0.001