Fig. 2

Role of SCARB2 and attachment receptors. SCARB2 is expressed abundantly in lysosomes but not at the cell surface. EV-A71 enters cells using attachment receptors. Attachment receptors cannot initiate conformational changes in the virion. Internalized viruses may encounter SCARB2 in endosomes, where uncoating takes place after acidification of these endosomes. hWARS may mediated a infection pathway distict from the SCARB2-dependent pathway. CypA may be involved in uncoating