Table 1 Summary of factors and effects after neural stem cell transplantation in 3xTg mice

 hCNS-SC

Hippocampus

↑immature neuron

↑immature glia cell

↑synaptic density

↑endogenous synaptogenesis

・The relation of endogenous synaptogenesis and hCNS-SC

・Role of neurotrophic factor

×

[43]

 GFP tg mice

relative to Bregma of: AP:_ 2.06, ML:_1.75, DV:_1.75

↑BDNF

↑synaptic density

・Axonal growth in vivo

×

[23]

 GFP-C57BL/6 mice

hippocampal CA1

NSC

↑neuronal regeneration

・Origin of newly synthesized neuron

・mechanism of neural regeneration

△

[44]

 GFP tg mice

hippocampus subiculum

NSCs delivered NEP

↑synaptic density

↓Aβ

・Link between Aβ level and cognitive deficit

〇

[45]