Fig. 1

Pathways of proinflammatory cytokine-induced protein degradation in rheumatoid cachexia. (ref [35, 40,41,42,43,44,45]). TNFα tumor necrosis factor-α, NFκB  nuclear factor kappa-light chain enhancer of activated B cells, IL-1β  interleukin-1β, PPARγ  peroxisome proliferator activated receptor-gamma