Fig. 7From: NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcomaProposed model of NKX6-1-mediated stemness signaling and cancer stemness properties in LMS. NKX6-1 activates SHH and NOTCH but not WNT, resulting in enhanced malignant phenotypes and poor prognosis in LMS. Inhibition of SHH but not NOTCH inhibits cell growth, suggesting the potential of SHH inhibitors for the treatment of LMSBack to article page