Fig. 2
From: Applications of brain organoids in neurodevelopment and neurological diseases
The applications of organoids in GBM modeling and antitumor drug screening. GBM organoid models can be generated by manipulating genes related to tumors with gene editing techniques, or coculturing the glioma stem cells (GSCs) and GBM spheroids derived from human tumors with brain organoids. GBM models can also be constructed by culturing freshly surgically removed tumor samples in optimized medium. In addition, the GBM organoid models have shown tremendous potential in screening effective antitumor drugs and developing the personal treatment for cancer patients