Fig. 2
From: Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases
The effect of LSD1 inhibition on anti-tumor immunity. LSD1 inhibition in cancer cells enhances tumor immunogenicity and secretion of chemokines that attract T cells, while reversing the resistance to PD-(L)1 blockade. LSD1 inhibition upregulates pro-inflammatory cytokines in Treg cells, promotes the polarization of macrophages into the anti-tumor M1-like macrophages, and enhances the infiltration of these macrophages and CD8 + T cells into the tumor