Fig. 3
From: Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases
LSD1 functions as a key epigenetic regulator in inflammatory disease. LSD1 controls gene expression in two ways during inflammation. LSD1 increases the expression levels of inflammatory response genes by acting as a positive regulator in inflammatory diseases such as rheumatoid arthritis (RA), sepsis, hepatitis B virus-associated glomerulonephritis (HBV-GN), and SARS-CoV-2 infection. By contrast, LSD1 functions as a negative regulator of the inflammatory response that decreases the expression of cytokine genes in smooth muscle cells (SMCs), cancer cells, and hematopoietic stem cells (HSCs)