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Fig. 8 | Journal of Biomedical Science

Fig. 8

From: USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3

Fig. 8

USP9X plays a suppressive role in cholangiocarcinoma progression. USP9X elicited tumor suppressor role by deubiquitinating EGLN3. Knockdown of EGLN3 decimated USP9X-mediated suppression of proliferation. USP9X positively regulated the expression level of apoptosis pathway genes KIF1Bβ through EGLN3 thus involved in apoptosis of cholangiocarcinoma. In conclusion, USP9X plays an inhibitory role in cholangiocarcinoma and serves as a biomarker for the treatment and diagnosis of cholangiocarcinoma

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Journal of Biomedical Science

ISSN: 1423-0127