Table 1 The use of drug-loaded microbubbles in conjunction with the US to treat tumors
Medication | Tumor type | The diameter of the microbubble | Microbubble type | Application | Reference |
|---|---|---|---|---|---|
DOX | Glioblastoma multiforme | 1.04 μm | Lipid-based | Evaluating the efficacy of BBB opening and medication transportation | [229] |
DOX | Malignant glioma | 4.00 μm | Lipid-based | The suppression rate of human glioblastoma cells is being investigated | [230] |
DOX | Pancreas carcinoma | 1.02 μm | Lipid-based | Pancreatic cancer treatment using a rat model | [229] |
DOX | Liver tumor | 1.50 μm | Poly(lactic acid)-based | Treating liver tumors in a rabbit model | [231] |
DOX | Breast cancer | 1.64 μm | Lipid-based | Examining the anticancer activity in human breast cancer cells | [232] |
Paclitaxel (PTX) | Ovarian cancer | 1.80 μm | Lipid-based | Treatment of ovarian cancer in a mouse model | [233] |
PTX | Ovarian cancer | 1.80 μm | Lipid-based | Evaluating the anticancer activity for ovarian carcinoma cells in human | [234] |
PTX | Breast cancer | 1.68 μm | Lipid-based | Breast cancer treatment efficacy in a mice model | [235] |
Docetaxel | Colon adenocarcinoma | 3.30 μm | Lipid-based | Researching the anticancer function on human colon adenocarcinoma cell line | [236] |
Hydroxycamptothecin | Liver tumor | 1.48 μm | Lipid-based | Accelerating the inhibitory rate of tumor | [237] |
Carmustine | Glioblastoma multiforme | 1.32 μm | Lipid-based | Assessing the glioma therapeutic effectiveness in a rat model | [229] |