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Table 1 The use of drug-loaded microbubbles in conjunction with the US to treat tumors

From: The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

Medication Tumor type The diameter of the microbubble Microbubble type Application Reference
DOX Glioblastoma multiforme 1.04 μm Lipid-based Evaluating the efficacy of BBB opening and medication transportation [229]
DOX Malignant glioma 4.00 μm Lipid-based The suppression rate of human glioblastoma cells is being investigated [230]
DOX Pancreas carcinoma 1.02 μm Lipid-based Pancreatic cancer treatment using a rat model [229]
DOX Liver tumor 1.50 μm Poly(lactic acid)-based Treating liver tumors in a rabbit model [231]
DOX Breast cancer 1.64 μm Lipid-based Examining the anticancer activity in human breast cancer cells [232]
Paclitaxel (PTX) Ovarian cancer 1.80 μm Lipid-based Treatment of ovarian cancer in a mouse model [233]
PTX Ovarian cancer 1.80 μm Lipid-based Evaluating the anticancer activity for ovarian carcinoma cells in human [234]
PTX Breast cancer 1.68 μm Lipid-based Breast cancer treatment efficacy in a mice model [235]
Docetaxel Colon adenocarcinoma 3.30 μm Lipid-based Researching the anticancer function on human colon adenocarcinoma cell line [236]
Hydroxycamptothecin Liver tumor 1.48 μm Lipid-based Accelerating the inhibitory rate of tumor [237]
Carmustine Glioblastoma multiforme 1.32 μm Lipid-based Assessing the glioma therapeutic effectiveness in a rat model [229]