Fig. 4
From: The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
miRNA-based therapy may encounter potential challanges in HD. miRNA-based therapy needs to overcome the miRNA instability, suitable delivery systems and functional effects inside brains. Nucleotide modifications, such as 2'-O-methyl- and phosphorothioate- structure, may increase the stability of miRNAs. Delivery systems, such as viruses, exosomes and nanoparticles, may faciliate the efficiency and safety to transport miRNAs into brains. Most importantly, several potential challenges which may be encountered inside brains are listed