Table 4 Pharmacokinetic parameter estimates of 29 plasma concentrations obtained using the PK model depicted in Fig. 2
From: Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent
Parameter | Estimate | Units | Standard error | CV% |
|---|---|---|---|---|
V | 5.36 | L/kg | 2.91 | 54.2 |
CL | 12.13 | L/h/kg | 2.02 | 16.7 |
Ka,po | 7.91 | 1/h | 6.18 | 78.1 |
V2 | 6.07 | L/kg | 1.55 | 25.5 |
CL2 | 10.44 | L/h/kg | 4.25 | 40.7 |
Fpo | 6.6 | % | 1.5 | 23.3 |
Ka,ip | 7.53 | 1/h | 4.23 | 56.2 |
FIP | 99.5 | % | 17.1 | 17.2 |