Fig. 6
From: HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression
HBx exacerbates LPS/D-GalN-induced ALF and ferroptosis in vivo. A The survival curve of WT + vehicle, HBx-Tg + vehicle, WT + LPS/D-GalN and HBx-Tg + LPS/D-GalN mice. The serum levels of B ALT and C AST were assessed. D The histopathological changes were determined by H&E staining. The levels of E MDA, F GSHand, G iron were assessed. H The immunoreactivity of SLC7A11 was determined by IHC analysis. I The protein levels of EZH2 and H3K27me3 in liver tissues were determined by western blot. *, P < 0.05, **, P < 0.01, ***, P < 0.001