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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors

Fig. 4

Kinetic parameters of FGF1-SA oligomers interaction with FGFR1. BLI-determined kinetic parameters of the interaction between FGF1 (A), FGF1-AviTag-Biot-SA-1A3D (B), FGF1-AviTag-Biot-SA-2A2D (C), FGF1-AviTag-Biot-SA-3A1D (D) or FGF1-AviTag-Biot-SA-4A (E) and FGFR1, respectively. The extracellular region of FGFR1 was immobilized on BLI sensors and incubated with various concentrations of FGF1-SA oligomers. KD, kon, and koff were calculated using global fitting with the 2:1 “heterogeneous ligand” with ForteBio Data Analysis 11.0 software (F)

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Journal of Biomedical Science

ISSN: 1423-0127