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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion

Fig. 5

Two lamivudine-resistant polymerase mutants are normal in virion secretion. A Polymerase mutants YIDD created corresponding changes in the overlapping envelope ORF—W196L and W196S. B No apparent defect in virion secretion was detected in two polymerase YIDD mutants containing envelope mutations W196L and W196S, respectively. Mutant W196L exhibited increased secretion of genome-containing virions. Virion-associated DNAs were quantified by densitometry and Image J software. C Virion-associated HBV DNA was analyzed by qPCR as described in Fig. 4B. HBV DNA signals of small loop mutants cotransfected with pMT-Pol were compared individually to the WT-HBV control. GE: genomic equivalent. Bar graph statistics by one-way ANOVA tests. ***P < 0.001; **P < 0.01

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Journal of Biomedical Science

ISSN: 1423-0127