Table 4 List of identified variants within inhA gene using long-read sequencing approach in susceptible or INH-resistance MTB isolates
Variants in inhA | Isolate no. | Variant no. | |
|---|---|---|---|
Susceptible only | Ser20Pro/Pro107Leu/Ala131Gly/Pro156Gln/Ile202Val/Gly212Cys/Ile228Phe/Thr236Ala | 10 | 8 |
Susceptible and Resistant | Gly14Glu/Ser20Pro/Arg27Leu/Ala75Pro/Ala81Thr/Ser94Trp/Ser152Gly/Ala72Pro | 52 | 9 |
Variants (identified copy) in inhA | Isolate no. | Variant no. | |
|---|---|---|---|
Low INH resistant isolate | His24Leu(2)/ Ala58Gly(2)/ Gly83Glu(2)/ Gly102Arg(2)/ Asn139Lys(5)/ Asp150Glu(7) Met232Leu(2) | 20 | 8 |
High INH resistant isolate | Lys8Gln(2)/ Gly83Arg(2)/ Ala72Asp(2)/ Phe97Ser(2)/ Lys132*(3)/ Pro136Arg(2)/ Pro151Leu(2) Pro151Arg(2)/ Ser166Asn(2)/ Cys243Arg(2) | 22 | 10 |
Low and High INH resistant isolate | Arg27Pro(2)/ Ala29Gly(2)/ Glu31Asp(2)/ Gly40Trp(4)/ Phe41Leu(4)/ Arg43Trp(4)/ Gln66Pro(4)Lys87Met(2)/ Lys132Glu(3)/ Lys132Gln(2)/ Pro140His(6)/ Leu168Phe(4)/ Glu219Gln(8)/ Glu219Asp(2) Asp223Asn(3)/ Trp2308(3)/ Thr254Pro(3)/ Gly262Asp(8)/ His265Tyr(4)/ Gln267His(7)/ Leu268Trp(5) | 42 | 21 |