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Table 1 [3H]VPA transporter kinetic parameters are altered between WT and MT ALS cell lines

From: Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis

Parameters

WT (NSC-34, hSOD1WT)

MT (NSC-34, hSOD1G93A)

Km1 (µM)

37.8 ± 3.0

19.1 ± 0.7**

Km2 (mM)

4.588 ± 0.620

1.144 ± 0.143**

Vmax1 (nmol/mg protein/10 s)

0.0083 ± 0.0044

0.0232 ± 0.0007**

Vmax2 (nmol/mg protein/10 s)

1.864 ± 0.244

0.231 ± 0.015***

  1. Data represent the mean ± standard error of the mean. Km1, Vmax1 (at high-affinity sites) and Km2, Vmax2 (at low-affinity sites) represent the transporter affinity and maximum transport velocity, respectively. **p < 0.01 and ***p < 0.001 versus WT
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Journal of Biomedical Science

ISSN: 1423-0127