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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression

Fig. 7

Global gene repertoire of miRNAs directly positively regulated by Sp1. The global repertoire of genes binding to Sp1 was studied by ChIP-Seq (A), and the binding sequence of Sp1 is shown here (B). The genomic region for Sp1 binding was analyzed (C). Genes positively regulated by Sp1 were studied by small RNA sequencing (D). The repertoire of miRNAs binding to Sp1 was studied by ChIP-Seq (E). The intersection between miRNAs positively and negatively regulated by Sp1 recruitment (F). Sp1-mediated miRNAs were analyzed by OncoMir to predict the candidate miRNAs targeting CD44, ALDH1, β-catenin and Sox2 (G)

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Journal of Biomedical Science

ISSN: 1423-0127