Fig. 7
07-IgG1 inhibits EV-A71 replication in mice. A Brain tissues from sacrificed mice were used for ENO1 and EV-A71 qPCR. B H&E stain was performed to analyze ventral striatum immune cells infiltration. Upper panel: 4 × objective; Lower panel: 40 × objective. Black arrows indicate the cluster of immune cell infiltration. C H&E and IHC stain of brainstem from sacrificed mice. Red arrows indicate gliosis and green arrows indicate necrotic and partially lytic forms of basophilic neuronal necrosis. *p < 0.05; **p < 0.001, ***p < 0.0001