Fig. 6
From: O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage
MRE11 is enriched on prostate cancer-specific mutation hotspots (small nucleotide polymorphisms). A Bar plots depicting mutational burden and B percentage of genome affected by the copy number gains or losses in MRE11 mutant and wild type prostate cancer patient samples. The plot was generated using cBioPortal and dataset Abida et al. (2019) [1]. C) Upset plot showing the overlap (at the level of gene-loci) between the previously published prostate cancer specific SNPs (GCST006085), and ChIP-seq data for O-GlcNAc (GSE121474) and for MRE11 (GSE63202)