Fig. 4

Combination treatment induced intracellular DNA damage as determined by Comet assay. Green fluorescent indicates Comet in PC/DX25 (A) and DU/DX50 (B) cells being treated with 25 nM or 50 nM docetaxel, respectively, in combination with increasing concentrations (0, 10, 20 and 40 µM) of CAPE for 96 h. Quantification of Comet tail in PC/DX25 cells (C) and DU/DX50 cells (D) was shown. The asterisks *, ** and *** represent p value < 0.05, p value < 0.01, and p value < 0.001, respectively