Skip to main content
Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts

Fig. 7

Schematic model of effect of C3A on DHT-induced mitochondrial calcium influx and DPC senescence. C3A effectively decreased DHT-induced mtROS accumulation and DPC senescence. HSP27 phosphorylation was modulated by p38-mediated signaling and it was involved in AR nuclear translocation. In turn, HSP27 phosphorylation is modulated by membrane AR-mediated signaling, which was inhibited by C3A. Remarkably, C3A inhibited p38-mediated VDAC1 expression that contributes to MAM formation and transfer of calcium via VDAC1–IP3R1 interactions. Finally, excessive mitochondrial calcium entry through MAM formation resulted in increase of DPC senescence, but C3A reduced the mitochondrial calcium influx under DHT exposure conditions

Back to article page

Journal of Biomedical Science

ISSN: 1423-0127