Fig. 5From: The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapyThe mechanism of neutrophil extracellular traps (NETs) [105]. NET is triggered by ROS. NE is translocated from azurophilic granules to the nucleus by MPO. NET releases after breakage of the plasma membrane. ROS, reactive oxygen species; NE, neutrophil elastase; MPO, myeloperoxidase; PAD4, peptidyl arginine deiminase 4; NETs, neutrophil extracellular traps. (Created with BioRender.com.)Back to article page