Fig. 3
Crystal structure of integrin αvβ3 (PDB code 1L5G) [95] with thyroxine (T4, red), resveratrol (RSV, blue), estradiol (E2, orange), and heteronemin (mode 1 shown in white and mode 2 shown in yellow) models into the RGD binding pocket. The green and cyan parts represent αv and β3 chains of integrin αvβ3 receptor. A Docking mode 1 (white stick) of the heteronemin maps to T4 (red), RSV (blue), and E2 (orange). B Docking mode 2 (yellow stick) of the heteronemin maps to T4 (red), RSV (blue), and E2 (orange). C Schematic representation of observed interactions between binding mode 1 (white) of heteronemin and pocket sites. D Schematic binding mode 2 (yellow) of heteronemin