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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD

Fig. 4

The TGF-β and JAK/STAT3 pathways are highly enriched in HCC clinical samples with increased DYRK1A expression. a and b Data collected from the LinkedOmics platform (www.linkedomics.org/admin.php) are shown. Sample cohort: The Cancer Genome Atlas_liver HCC; Institute: UNC; Data type: RNAseq; Platform: HiSeq RNA; Attribute: DYRK1A; Statistical methods: Pearson correlation test; Patients: 371; Tool: GSEA, Enrichment Categories: a PANTHER pathways and b WikiPathways. c The TGF-β, JAK/STAT3 and EGF/EGFR signalling pathways were enriched in the DYRK1A high expression group in both the WikiPathways and PANTHER pathways analyses. d and e GSEA was performed, and the results indicated that DYRK1A could play an important role in regulating the TGF-β and JAK/STAT3 pathways

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Journal of Biomedical Science

ISSN: 1423-0127