Fig. 8From: DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMADDYRK1A promotes EMT by activating a cooperative STAT3/SMAD gene transcription program. a HCC cells were incubated with DYRK1A siRNA or negative control siRNA for 48Â h, and an immunofluorescence assay was then performed. b The interaction of STAT3 and SMAD2/3 in empty vector and DYRK1A overexpression group. c HCC cells were transfected with DYRK1A siRNA or the STAT3 overexpression plasmid for 48Â h, and western blot analysis was then performedBack to article page